Identify the brain structures involved in attention. Relate the changes in neurotransmitter(s) in ADHD to the utility of methylphenidate in treating the disorder. Include in your answer the mechanism of action of the medication. (Sigs 8.8a)
Dopamine and norepinephrine in appropriate amounts required for optimal functioning of prefrontal cortex, subcortical structures, and cerebellum
Explain why the therapeutic effects of SSRIs are delayed. (SIGS 8.6a)
reuptake inhibition initially, but may require additional "downstream" effects to produce full therapeutic effect; modifies serotonergic receptors over weeks
Discuss splitting, transference, and countertransference in Borderline Personality Disorder (Sigs 8.8b)
S: only good v. bad w/ no in between; T: subconscious associat. person in present w/ a past relationship; C: responding in present w/ thoughts/feelings of past
Describe the mechanism of action of buprenorphine for the treatment of opioid use disorder. (SIGS 8.7b)
mu partial agonist, narcotic analgesic, morphine type (synthetic); used to prevent relapse
Describe the brain circuits implicated in the symptoms of schizophrenia. (SIGS 8.6b)
Describe how atypical antipsychotics treat symptoms of schizophrenia AND list adverse effects associated with these medications. (SIGS 8.6b)
transiently occupy D2 recep and rapidly dissociate to allow normal dopamine transmission; 2nd gen less potent D2 antagonists + antagonize 5HT2 recep to decr AE
List the symptoms of alcohol withdrawal and the timing of their presentation. (SIGS 8.7a)