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Unit 6B Bugs
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Which pathogens are high resistant pathogens?
ESKAPE causing most nosocomial infections worldwide (e. faesium, s. aureus, k. pneumoniae, a. baumannii, p. aeruginosa, e. coli)
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What are major virulence of uropathogenic e. coli?
hemolysin A (lysis of cells for output of iron), siderophore (for iron chelation)
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What is the most common cause of UTIs?
E. coli
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What is the most distinguishing virulence of p. mirabilis?
lactose non-fermenter (fermenterse being k.pneumo and e.coli). others: urease + (forming struvite stones), motile
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What are some virulence and characteristics of n. gonorrhea?
gram - diplococci, glucose fermenter, pili + antigenic variation (so not able to make vaccine)
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What are possible treatments for p. miribalis UTI?
(IV administration) carbapenem, fluoroquinolones, cephlasporin XL + aminoglycosides, penicilin XL special (Zosan: pep + tazo)
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What pathogens are most resistant to Beta-lactams?
SPACE because they have a gene that encodes for beta-lactamases. (s. marcenscens, p. aeruginosa, acinetobacter, citrobacter, and e. coli)
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What is the management plan for an STI-related UTI?
ceftriaxone (IM), abstaining from sex x1 wk, treat sexual partners, for c. trachomatis use doxycycline
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What are the top causes of STI-relates UTIs?
n. gonorrhea, c. trachomatis, and HSV-2
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What are possible treatment for s. saprophyticus UTI?
nitrofurantoin (macrobid), TMP-SMX (bactrim), and fluoroquinolones (depending on resistance in the community)
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What are the ways pathogens ascend and infect the urinary tract?
gram -, motility to swim up, fimbrae for attachment, colonization, biofilm formation
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What is the most distinguishing virulence of s. saprophyticus in relation to other of its species?
novobicin resistant, which inhibits ATP production. others: binds fibronectin, biofilm, urease +, catalase +
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What is a unique virulence to k. pneumoniae?
carbapenemase (making it resistant to cephalsporins)
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