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Pharmacology Chapter 11: Antianxiety Agents

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  • What are the two main types of sedative-hypnotic drugs?
    Benzodiazepines and Barbiturates
  • What percent of people only go to the dentist when absolutely necessary?
    20%
  • Benzodiazepines are well-absorbed when administered which way?
    Orally
  • What is a use for a muscle relaxant that is related to dentistry?
    Treatment of temporormandibular disorder (TMD)
  • What are the most commonly prescribed antianxiety drugs?
    Benzodiazepines
  • Which two benzodiazepines are used to treat seizures?
    Diazepam and Clonazepam
  • What major depressant should be avoided when taking benzodiazepines?
    Alcohol
  • Benzodiazepines are metabolized in the?
    Liver
  • Which barbiturate agent is used in the treatment of epilepsy?
    Phenobarbital
  • What can occur with overdose of barbiturates?
    Cardiovascular and respiratory depression
  • What is the naturally occurring hormone that is manufactured synthetically and used to treat insomnia?
    Melatonin
  • What does the normal sedative dose do?
    Reduces simple anxiety
  • What does the hypnotic dose do?
    Induces sleep
  • Side effects of benzodiazepines and barbiturates are more likely to occur in _______ persons.
    Elderly
  • What percent of people refuse to seek any dental care due to anxiety?
    7%
  • What are the four dental effects that can occur when taking benzodiazepines?
    Xerostomia, increased salivation, swollen tongue, bitter or metallic taste
  • Benzodiazepines facilitate what type of transmission?
    GABA-meditated
  • What hypnotic drug can be used in dentistry for a patient that has trouble falling asleep the night before a dental appointment?
    Zolpidem
  • Which sedative-hypnotic agent is called anxioselective and produces much less CNS depression?
    Buspirone
  • True/False: Anxiety can increase the pain threshold
    False
  • Benzodiazepines rapid onset is related to its?
    Lipid solubility
  • Which agent is termed the "original sedative-hypnotic agent?"
    Barbiturates
  • What are the two major uses for barbiturates?
    Seizures and inducing general anesthesia
  • Which agents have completely replaced barbiturates in treating anxiety?
    Benzodiazepines
  • Name 3 different examples of benzodiazepines
    Alprazolam (Xanax), Chlordiazepoxide (Librium), Diazepam (Valium), Lorazepam (Ativan), Midazolam (Versed), Triazolam (Halcion)
  • True/False: Psychological management must accompany the use of antianxiety agents
    True