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Pharmacology Chapter 11: Antianxiety Agents
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What are the two main types of sedative-hypnotic drugs?
Benzodiazepines and Barbiturates
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What percent of people only go to the dentist when absolutely necessary?
20%
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Benzodiazepines are well-absorbed when administered which way?
Orally
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What is a use for a muscle relaxant that is related to dentistry?
Treatment of temporormandibular disorder (TMD)
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What are the most commonly prescribed antianxiety drugs?
Benzodiazepines
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Which two benzodiazepines are used to treat seizures?
Diazepam and Clonazepam
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What major depressant should be avoided when taking benzodiazepines?
Alcohol
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Benzodiazepines are metabolized in the?
Liver
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Which barbiturate agent is used in the treatment of epilepsy?
Phenobarbital
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What can occur with overdose of barbiturates?
Cardiovascular and respiratory depression
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What is the naturally occurring hormone that is manufactured synthetically and used to treat insomnia?
Melatonin
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What does the normal sedative dose do?
Reduces simple anxiety
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What does the hypnotic dose do?
Induces sleep
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Side effects of benzodiazepines and barbiturates are more likely to occur in _______ persons.
Elderly
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What percent of people refuse to seek any dental care due to anxiety?
7%
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What are the four dental effects that can occur when taking benzodiazepines?
Xerostomia, increased salivation, swollen tongue, bitter or metallic taste
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Benzodiazepines facilitate what type of transmission?
GABA-meditated
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What hypnotic drug can be used in dentistry for a patient that has trouble falling asleep the night before a dental appointment?
Zolpidem
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Which sedative-hypnotic agent is called anxioselective and produces much less CNS depression?
Buspirone
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True/False: Anxiety can increase the pain threshold
False
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Benzodiazepines rapid onset is related to its?
Lipid solubility
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Which agent is termed the "original sedative-hypnotic agent?"
Barbiturates
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What are the two major uses for barbiturates?
Seizures and inducing general anesthesia
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Which agents have completely replaced barbiturates in treating anxiety?
Benzodiazepines
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Name 3 different examples of benzodiazepines
Alprazolam (Xanax), Chlordiazepoxide (Librium), Diazepam (Valium), Lorazepam (Ativan), Midazolam (Versed), Triazolam (Halcion)
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True/False: Psychological management must accompany the use of antianxiety agents
True
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