What's the matter with her?
She has a cough.
What's the matter with her?
She has a fever. / She has a temperature.
What's the matter with him?
He feels sick. / He feels nauseated.
What's the matter with her?
She has a stomachache.
What's the matter with her?
She has a toothache.
What's the matter with her?
She has allergies. / She's sneezing.
What's the matter with him?
He has a sore throat.