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action potential blocking disorders
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causes flaccid paralysis
botulism/botox
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I can't feel my face, am I smiling?
botox
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treatment for severe underarm sweating and facial wrinkles
botox
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blocks adenosine receptors in the brain's arousal system
caffine
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Fugu, made from pufferfish, edible only if poison is removed, Japanese delicacy
tetrodotoxin
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nicotinic ACh receptors are inhibited by
curare
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blocks re-uptake transporters for dopamine, norepinephrine and serotonin
cocaine
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toxin cleaves SNARE protien
botox/botulism
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Don't eat the pufferfish it's poisonous!
tetrodotoxin
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active ingredient is tubocurarine, used in blow darts to paralyze prey
Curare
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antibodies block and destroy ACh receptors
Myasthenia gravis
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ACh degradation is blocked, muscle continues to contract causing paralysis
nerve gas
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starts with spastic paralysis but ends with flaccid paralysis
nerve gas
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Inhibits ACh esterase activity
nerve gas and pesticides
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blepharospasm and strabismus treatment
botox
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Block voltage gated channels on sensory neurons
"caines"
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can cause nausea, camps, lack of coordination and difficulty breathing; death can occur from respiratory failure
black widow venom
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neostigmine, physostigmine
myasthenia gravis treatment
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produced by the bacterium Clostridium botulinum
botulism
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triggers explosive release of ACh from storage vesicles at the NMJ and cholinergic sites
black widow venom
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Russian spy and avenger
black widow
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there is no antidote to this toxin, can cause paralysis and asphyxiation
tetrodotoxin
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botulinum toxin inhibits release of ACh at the neuromuscular junction
botulism
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prolonged use decreases overall synthesis of dopamine
cocaine
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progressive weakening of skeletal muscles
myasthenia gravis
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inhibits release of ACh, used medically for cervical dystonia
botox
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blocks voltage-gated Na+ channels
tetrodotoxin
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often used in drugs that are used during surgery
curare
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Okay!
causes muscle paralysis by blocking voltage gated Na+ channels
tetrodotoxin
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binds to and blocks ACH receptors, relaxes skeletal muscle
curare
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