What is the matter with her?
She has a toothache.
What is the matter with you?
I have a backache.
What is the matter with her?
She has a stomach-ache.
What is the matter with him?
He has a headache.
What is the matter with you?
I have a sore throat.
What is the matter with him?
He has sore eyes.
What is the matter with you?
I have a ferver.