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action potential blocking disorders
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Don't eat the pufferfish it's poisonous!
tetrodotoxin
I can't feel my face, am I smiling?
botox
Russian spy and avenger
black widow
Block voltage gated channels on sensory neurons
"caines"
nicotinic ACh receptors are inhibited by
curare
can cause nausea, camps, lack of coordination and difficulty breathing; death can occur from respiratory failure
black widow venom
triggers explosive release of ACh from storage vesicles at the NMJ and cholinergic sites
black widow venom
starts with spastic paralysis but ends with flaccid paralysis
nerve gas
ACh degradation is blocked, muscle continues to contract causing paralysis
nerve gas
Inhibits ACh esterase activity
nerve gas and pesticides
blocks adenosine receptors in the brain's arousal system
caffine
prolonged use decreases overall synthesis of dopamine
cocaine
blocks re-uptake transporters for dopamine, norepinephrine and serotonin
cocaine
there is no antidote to this toxin, can cause paralysis and asphyxiation
tetrodotoxin
Fugu, made from pufferfish, edible only if poison is removed, Japanese delicacy
tetrodotoxin
causes muscle paralysis by blocking voltage gated Na+ channels
tetrodotoxin
blocks voltage-gated Na+ channels
tetrodotoxin
toxin cleaves SNARE protien
botox/botulism
binds to and blocks ACH receptors, relaxes skeletal muscle
curare
often used in drugs that are used during surgery
curare
active ingredient is tubocurarine, used in blow darts to paralyze prey
Curare
treatment for severe underarm sweating and facial wrinkles
botox
blepharospasm and strabismus treatment
botox
inhibits release of ACh, used medically for cervical dystonia
botox
botulinum toxin inhibits release of ACh at the neuromuscular junction
botulism
produced by the bacterium Clostridium botulinum
botulism
causes flaccid paralysis
botulism/botox
neostigmine, physostigmine
myasthenia gravis treatment
progressive weakening of skeletal muscles
myasthenia gravis
antibodies block and destroy ACh receptors
Myasthenia gravis


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