Identify risk and protective factors for suicide. (SIGS 8.6a)
risk: previous attempt, mental illness, social isolation, financial/legal/health problems, substance use, impulsive; protect: coping, religion, social support
15
Describe the mechanism of action of SSRIs and SNRIs. (SIGS 8.6a)
SSRI: inhibit 5-HT reuptake; SNRI: inhibit 5-HT & NE reuptake
15
Explain why the therapeutic effects of SSRIs are delayed. (SIGS 8.6a)
reuptake inhibition initially, but may require additional "downstream" effects to produce full therapeutic effect; modifies serotonergic receptors over weeks
15
Describe neurochemical changes thought to underlie the symptoms of schizophrenia. (SIGS 8.6b)
Describe how atypical antipsychotics treat symptoms of schizophrenia AND list adverse effects associated with these medications. (SIGS 8.6b)
transiently occupy D2 recep and rapidly dissociate to allow normal dopamine transmission; 2nd gen less potent D2 antagonists + antagonize 5HT2 recep to decr AE
15
Describe the brain circuits implicated in the symptoms of schizophrenia. (SIGS 8.6b)