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NSG123 Module 14: Musculoskeletal

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    Osteo and Gout
  •   Study   Slideshow
  • What are the administration instructions for alendronate (Fosamax)?
    1 oral dose once weekly; take with full glass of water (not juice or coffee) at least 30 mins prior to breakfast/other drugs; remain upright 30 min after
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  • What are the roles of osteoclasts and osteoblasts?
    Osteoclasts (clear) dissolve bone and clear away old bone. Osteoblasts (build) are cells that form new bone.
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  • Name 5 risk factors for osteoporosis.
    Alcohol, tobacco, family hx, bone fx during adult, inactive, low ca and vit d, low BMI, Malabsorption disorders, men over 60, postmeno women, long-term corticos
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  • What is secondary osteoporosis?
    Due to medication use or disease that affect bone metabolism (men more likely)
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  • How is osteoporosis diagnosed?
    DEXA (Dual Energy x-ray absorptiometry)
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  • What types of exercise promote bone formation?
    Weight-bearing; 20-30 min aerobic, bone-stressing exercise; Weight training
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  • What are signs of hypercalcemia?
    N/V, ab pain, constipation, Drowsiness, Disorientation, dysrhythmias, lower extremity weakness, polyuria, polydipsia
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  • What are administration instructions for zoledronic acid (Reclast)?
    IV once yearly
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  • Describe denosumab (Prolia) administration.
    Sub q every 6 months
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  • Name 3 osteoarthritis risk factors.
    Older age, female, obesity, laborious occupations, excessive sports, history of joint injuries, genetic predisposition
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  • What causes gout?
    hyperuricemia
  •  15
  • Name 5 risk factors for gout.
    Male, obese, alcohol, fam hx, high bp, hypothyroidism, CKD, OSA, T2DM, Cancer, Psoriasis, Hemolytic Anemia
  •  15
  • What are the 4 stages of gout?
    Asymptomatic Hyperuricemia, Acute Gouty Arthritis, Intercritical Gout, Chronic Tophaceous Gout
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  • What can trigger a gout attack?
    trauma, alcohol, dieting, medications, surgical stress, illness
  •  15
  • Explain colchicine use.
    anti-gout, do not take with grapefruit juice or alcohol, caution in liver impairment
  •  15
  • Explain allopurinol use.
    reduces serum uric acid levels, caution in renal and hepatic impairment, take after meals to ensure absorption
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