What does Ranson's criteria evaluate? Is it better to have a high or a low score?
Assesses pancreatitis severity and risk of mortality; mortality liklihood increases w/ higher score
15
Hypocalcemia in the context of acute pancreatitis indicates
Fat necrosis (saponification)
15
What demographic is most likely to precipitate cholestrol gallstones? (Remember the F's)
Female, Forty, Fat, Fertile
10
What protein is released with insulin from pancreatic ß-cells?
c-peptide
15
What is the relationship between GLP-1 receptor agonist and DDP-4 inhibitors?
GLP-1 binds to α-cells in the pancreas (and more) and prevents glucagon secretion (↓ catabolism). DPP-4 inhibits GLP-1
25
Compare and contrast how liver enzyme labs would differ between pancreatitis and NAFLD
Pancreatitis ↑Alk phos ↑GGT; NAFLD ↑AST<↑ALT
15
Describe the biochemical pathway of lipid and carbohydrate metabolism and how it contributes to dyslipidemia
TG packaged as chylomicrons → Apo CII binds to LPL ↑FA deposition into adipose & muscle → remnant travels to liver endocytosed by LDLR →repackaged as vLDL