Unit 5 SIGS Review | Baamboozle - Baamboozle | The Most Fun Classroom Games!

English 19 Public

Unit 5 stuff

Study Slideshow

What is the MOA of loperamide?

Binds to mu-opioid receptors and decreases peristalsis

15

How does heat labile toxin exert its effects in Enterotoxogenic E. coli?

Catalyzes ADP ribosylation and stimulates adenylate cyclase to increase cAMP --> hypersecretion of water and electrolytes into bowel lumen

20

Name 4 out of 5 osteopathic models of care

Biomechanical, Neurological, Respiratory-circulatory, Metabolic, Behavioral

20

What is the most clinically important sequalae of Barrett's esophagus?

esophageal adenocarcinoma

15

Name 2 risk factors for peptic ulcer disease

Helicobacter pylori, chronic NSAID use, Zollinger-ellison syndrome

15

Outline the pathogenesis of Helicobacter pylori infection

bacteria ingested --> organism colonizes the stomach using urease to protect from gastric acid --> host inflammatory response damages mucosa --> bacteria invade

25

What is the MOA of Rotatvirus's NSP4 protein?

Alters calcium ion influx into enterocytes and disrupts the tight junctions, causing water to leak into the bowel lumen

15

What chapman point is at the right medial 5th and 6th intercostal space?

Liver (posterior TP = right T5 and T6 transverse processes)

10

1) Describe Cullen's sign, Grey Turner's sign, or Fox's Sign 2) What do those findings indicate?

1) (C) periumbilical ecchymosis; (GT) flank ecchymosis; (F) ecchymosis over inguinal ligament. 2) Acute pancreatitis

15

What does Ranson's criteria evaluate? Is it better to have a high or a low score?

Assesses pancreatitis severity and risk of mortality; mortality liklihood increases w/ higher score

15

Hypocalcemia in the context of acute pancreatitis indicates

Fat necrosis (saponification)

15

What demographic is most likely to precipitate cholestrol gallstones? (Remember the F's)

Female, Forty, Fat, Fertile

10

What protein is released with insulin from pancreatic ß-cells?

c-peptide

15

What is the relationship between GLP-1 receptor agonist and DDP-4 inhibitors?

GLP-1 binds to α-cells in the pancreas (and more) and prevents glucagon secretion (↓ catabolism). DPP-4 inhibits GLP-1

25

Compare and contrast how liver enzyme labs would differ between pancreatitis and NAFLD

Pancreatitis ↑Alk phos ↑GGT; NAFLD ↑AST<↑ALT

15

Describe the biochemical pathway of lipid and carbohydrate metabolism and how it contributes to dyslipidemia

TG packaged as chylomicrons → Apo CII binds to LPL ↑FA deposition into adipose & muscle → remnant travels to liver endocytosed by LDLR →repackaged as vLDL

25