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This rare but serious side effect of statins is diagnosed by measuring serum creatine kinase
Rhabdomyolysis
What are the adverse side effects of statins?
Main: Muscle Pain
others: Headache, weakness, fatigue, dizziness; malaise; GI complaints; increased blood glucose
What changes and supplements can be taken to improve statin related myalgias (muscle pain)?
Supplements: Vitamin D, CoQ10
Change the Statin
High potency statin at lower dose given less frequently
What lifestyle activities are associate risk factors of ASCVD?
Smoking
Decreased physical activity
Standard American Diet
What diseases are associated risk factors of ASCVD?
Diabetes
Hypertension
Hyperlipidemia
What risk factors are associated with ASCVD that are not lifestyle activities and or diseases?
Age >45 men; Age> 50 women
Family history
Differentiate between primary, secondary and tertiary risk reduction?
Primary: prevent atherosclerosis
Secondary: prevent damage from the atherosclerosis
Tertiary: Prevent further damage after a cardiac event
Explain the Mayo Clinic Statin Choice Decision Aid
Calculates your risk of having a heart attack in the next 10 years based on your risk factors
Deciding whether or not to go on a statin, a primary prevention
What are the components of the UnDo IT?
Eat Better
Move More
Stress Less
Love More
What are the benefits and potential problems with the UnDo IT program?
Benefits: great lifestyle choices
Problems: cost, time consuming
Describe treatment and management of ASCVD
lifestyle changes
Antiplatelet therapy if you have had a heart attack already
beta-blocker medication
statins
Prevalence of ASCVD in the US
Leading cause of death in the US (1 out of 4)
Affects races roughly equally
Roughly 6% of the population has heart disease
220 billion dollar cost burden
What are the benefits of Statins?
decrease cholesterol
protect against heart attack and stroke
generally safe, highly effective
What are the cholesterol levels that are measured in a lipid panel?
HDL
LDL
Triglycerides
Total Cholesterol
Discuss the sequela of ASCVD
Coronary Artery Disease (CAD)
Cerebral vascular disease
Peripheral Vascular disease
What is Creatine Kinase?
CK is a type of protein, known as an enzyme
