What therapy uses autologous T-cells engineered to express a specific T-cell receptor that makes the T cells recognize tumor cells and destroy them?
CAR T-cell therapy
CAR battery therapy
T-cell battering therapy
CAR B-cell therapy
Which statement about CAR T-cell therapy is FALSE?
Useful in treating chemo refractory disease
CAR T-cells can be directed to specific antigens
It creates immediate graft versus host disease
Can be used independent of or in addition to a BMT
Which of the following conditions are NOT treated with CAR T-cell therapy?
Acute Lymphoblastic Leukemia
Aplastic anemia
Multiple Myeloma
Lymphoma
Where do the T-cells come from that are engaged in BiTE therapy?
The patient's own T-cells
They are harvested from actual bite wounds
A donor's T-cells
A friend of a friend's T-cells
Patients that receive immune effector cell therapy are most at risk for which 2 serious side effects?
Cytokine Release Syndrome & neurologic toxicities
Cytokine Restraint Sickness & nephrotoxicity
Sickle cell conversion & myeloablation
There are NO side effects.
What is the BEST thing a nurse can do to recognize and intervene for IEC related adverse effects?
Frequent assessments with CRS & ICE/ICANS screening tools.
Infrequent assessments with CRP and ICAN'T screening tools.
Facebook thoughts and prayers.
Remind the attending physician every hour to assess the pt.
A patient has completed IEC therapy. Their VS are: T - 99.1*F, P 96, BP 104/70, O2 sat 98% on RA. Grade the CRS.
Grade 0
Grade 4
Grade 6
Grade 2
A patient completed IEC therapy 4 days ago. Their VS are T - 101*F, P 112, BP 100/56, O2 Sat 93% on 2L via NC. Grade the CRS
Grade 2
Grade 4
Grade 0
Grade 1
The nurse is completing the ICE assessment on a patient that has received IEC therapy. What is a "perfect" ICE score?
1
10
100
50
The nurse is completing the ICE assessment on a patient that has received IEC therapy. Abnormals: patient states the year is 2016, they identify 2 out of 3 objects correctly and they can't count backwards from 100. What is their ICE score?
1
7
10
3
The nurse is completing the ICE assessment on a patient that has received IEC therapy. The patient does not get a perfect score. What does the nurse do NEXT?
Complete the ICANS assessment by assigning a grade.
Wait 6 hours and rescreen the patient.
Ask the medical student to round on this patient 1st.
Reorient the patient and reassess after coaching them.
The nurse completes the ICE assessment and the patient scores 7. The patient awakens spontaneously and has no seizures or other notable neurologic deficits. What grade is their ICANS?
Grade 3
Grade 1
Grade 2
Grade 0
The nurse completes the ICE assessment and the patient scores 3. The patient awakens to light sternal rub and has no seizures or other notable neurologic deficits. What grade is their ICANS?
Grade 4
Grade 2
Grade 3
Grade 10
Prior to the administration of CAR T therapy, the facility must have at LEAST ___ doses of Tocilizumab available.
12
2
4
1
A patient that has received CAR T therapy has a CRS grade of 2 (temp 100.9*F, BP 88/48) and is not responding to the 2nd 1000 mL fluid bolus. Which orders would the nurse anticipate?
Continue to monitor the patient.
Give steroids and turn down the infusion.
Give a 3rd bolus and ibuprofen.
Give tylenol & tocilizumab, transfer to ICU for vasopressors
A patient that has received CAR T-cell therapy today asks the nurse when they can drive again. Which answer by the nurse is correct?
"Never"
"At least 8 weeks"
"At least 4 months"
"As soon as the benadryl wears off"
