What does Ranson's criteria evaluate? Is it better to have a high or a low score?
Assesses pancreatitis severity and risk of mortality; mortality liklihood increases w/ higher score
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10
Explain the relationship between cirrhosis and ascites
Liver insufficiencyโ portal hypertensionโ โ pressure within hepatic circulation โfluid exudes from plasma in capillaries into interstitial tissues
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15
What protein is released with insulin from pancreatic ร-cells?
c-peptide
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boom
Lose 50 points!
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gold
Win 50 points!
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rocket
Go to first place!
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banana
Go to last place!
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25
How does gluten cause dermatitis herpatiformis?
Genetically predisposed individuals develop IgA antibodies to gluten, which cross-reacts with reticulin in lamina propria. Injury and inflammation =blister
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15
1) Describe Cullen's sign, Grey Turner's sign, or Fox's Sign 2) What do those findings indicate?
What is the relationship between GLP-1 receptor agonist and DDP-4 inhibitors?
GLP-1 binds to ฮฑ-cells in the pancreas (and more) and prevents glucagon secretion (โ catabolism). DPP-4 inhibits GLP-1
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25
Outline the pathogenesis of Helicobacter pylori infection
bacteria ingested --> organism colonizes the stomach using urease to protect from gastric acid --> host inflammatory response damages mucosa --> bacteria invade
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25
Describe the biochemical pathway of lipid and carbohydrate metabolism and how it contributes to dyslipidemia
TG packaged as chylomicrons โ Apo CII binds to LPL โFA deposition into adipose & muscle โ remnant travels to liver endocytosed by LDLR โrepackaged as vLDL