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how do you diagnose toxicodendron dermatitis?
Clinically by look of skin and by HPI from patient but no need for special testing (skin test)
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About how many hours does it usually take to develop an itchy rash from urushiol oil?
24-48 hours (delayed response)
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General mechanism of action for a corticosteroids
downregulate expression of inflammatory cytokines, reduce activity immune system
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monster
Reset all scores!
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gold
Win 50 points!
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gift
Win 25 points!
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baam
Lose 15 points!
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5
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What is the first line of treatment with Toxicodendron dermatitis?
Washing with soap and water as soon as possible
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What do macrophages release (3 things) that cause tissue damage?
Lysosomal enzymes, Complement components, reactive species
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Do CD4+ helper T-cells recognize MHC I or II?
MHC II
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What caused the bullae to develop in Toxicodendron Dermatitis?
CD8 T cells caused keratinocyte apoptosis->loss cellular adhesion->spongiosis->papule->bullae/vesicle
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heart
Other team wins 20 points!
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fairy
Take points!
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fairy
Take points!
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lifesaver
Give 10 points!
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What is cell mediated immunity?
adaptive immunity which is mediated by activated, antigen-specific T cells
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What type of medication can suppress the immune system of someone with Toxicodendron dermatitis?
Systemic Corticosteriods
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What can early withdrawal of steroid therapy lead to with Toxicodendron dermatitis?
recrudescence of the lesions.
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baam
Lose 25 points!
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fairy
Take points!
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shark
Other team loses 20 points!
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banana
Go to last place!
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5
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What is the elicitation phase in allergic contact dermatitis?
Re-exposure to haptens->type IV hypersensitivity reaction-> sensitized Tcells circulate to skin where antigen is
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Define Type I hypersensitivity reaction
reaction mediated by IgE antibodies.
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Define type IV Hypersensitivity reaction
delayed cell-mediated immune reaction; involves T cells (CD4 or CD8) with antigens
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