How do glucocorticoids reduce an immune response? Which immune cells are most suppressed?
By decreasing gamma-interferon, IL-1 and 2 they decrease the activation and recruitment of T cells. This also decreases B cells, macrophage, and neutrophils
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15
Corticosteroids have a dose dependent action. When applying prednisolone, which animal would most likely need a higher dose (stronger effect); a dog with chronic atopy or a cat with IMHA?
A cat with IMHA. Immunosuppressive actions would require a dose that could act more systemically and on more receptors
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15
Provide the drug used as a mineralocorticoid in animals with Addison's disease
Fludrocortisone
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15
What are the common routes of administration for corticosteroids? Why would you not use ONE of the routes?
PO (tablet or liquid), IM or IA injection, topical. No IV b/c insoluble esters have slow absorption & anti-inflammatory effects with HPAA suppression
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15
What would be the clinical classification of the following skin lesions?
Chronic Atopy; Atopic dermatitis
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15
What is the law of corneal ulcers?
NEVER GIVE A CORTICOSTEROID IN THE PRESENCE OF A CORNEAL ULCER. Collagenase from bacteria increases, slows epithelial regeneration, will melt the eye
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15
How do glucocorticoids initiate labour?
Mimics foetal cortisol and initiates PGF2a to begin uterine contraction and cervical dilation
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15
What is the law of NSAIDs?
NEVER GIVE CORTICOSTEROIDS WITH NSAIDS!!!! Synergistic...except if topical CSt with systemic NSAID...and if a horse cuz fuck why not
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15
What are the ONLY 2 instances you ever use corticosteroids for shock?